Currently, GREAT supports recent assemblies of the well-annotated human (UCSC hg38 and UCSC hg19), and mouse (UCSC mm10 and UCSC mm9). The previous assembly versions of human and mouse genomes as well as zebrafish (UCSC danRer7) genome is supported in the previous versions of GREAT. Please check Genes pages for the list of genes included in the GREAT analysis in each genome assemby.
If you have genomic regions defined for a different species or assembly from the ones we currently support, you can use the UCSC LiftOver utility to convert to a supported assembly. The LiftOver typically works very well for within-species coordinate conversion (e.g. from one human assembly to another), but it can also be used as the best approximation of mapping regions in one genome to the orthologous regions of a genome for a different species (e.g., from chimpanzee to human), although more caution is obviously advised in these cases.
We do hope to gradually expand the set of species we support. GREAT needs the following to consider adding a new species:
For vertebrate species, you can help us consider additional species by sending us specific links to rich gene annotation resources unique to your species of interest.
For species more distantly related to human (e.g. drosophila or arabidopsis) we will likely not do the curation ourselves. However, if you are seriously interested and capable, we can consider sharing our file format requirements with you and have you contribute this species into GREAT.
Here's what you'll need to do:
And that's it. Interested parties are welcome to contact us for more detailed instructions.